Arabidopsis thaliana cryptochrome 2 (AtCRY2), a light-sensitive photosensory protein, was
previously adapted for use in controlling protein–protein interactions through light-dependent …

Transition metals are essential enzyme cofactors that are required for a wide range of
cellular processes. Paradoxically, whereas metal ions are essential for numerous cellular …

Melanoma and other cancers harbor oncogenic mutations in the protein kinase B-Raf,
which leads to constitutive activation and dysregulation of MAP kinase signaling. In order to …

Genetically encoded sensors based on fluorescence resonance energy transfer (FRET) are
powerful tools for reporting on ions, molecules and biochemical reactions in living cells. …

Fluorescent sensors are powerful tools for visualizing and quantifying molecules and ions in
living cells. A variety of small molecule and genetically encoded sensors have been …

Objective Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D).
Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection …

Objective Diabetes occurs because of insufficient insulin secretion due to β-cell dysfunction
within the islet of Langerhans. Elevated glucose levels trigger β-cell membrane …

Over half of all deaths among chronic kidney disease (CKD) patients are due to cardiovascular
disease (CVD). The risk of CVD mortality in CKD patients is 20-30 times higher than that …

In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory
cytokines can disrupt insulin secretion and Ca 2+ homeostasis. Connexin36 (Cx36) gap …

Using an intense powder mixture of Al2O3 with different copper contents (1, 5, 10, 20 or 30
mass%) several Al2O3-Cu composite materials were fabricated. The microstructure of the …