Hypertrophic Cardiomyopathy (HCM) is a common primary cardiac disorder defined by a
hypertrophied left ventricle, is one of the main causes of sudden death in young athletes, and …

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments
orchestrated by rising and falling Ca 2+ levels. Thin filaments are comprised of two actin …

Background Mutations in cardiac troponin T (TnT) are linked to increased risk of ventricular
arrhythmia and sudden death despite causing little to no cardiac hypertrophy. Studies in mice …

Collagen XIV is a fibril-associated collagen with an interrupted triple helix (FACIT). Previous
studies have shown that this collagen type regulates early stages of fibrillogenesis in …

In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to
0.45 mol of phosphate/mol by cardiac myosin light chain kinase (cMLCK) increases Ca 2+ …

Cardiac contraction depends on molecular interactions among sarcomeric proteins coordinated
by the rising and falling intracellular Ca 2+ levels. Cardiac thin filament (cTF) consists of …

Restrictive cardiomyopathy (RCM) is a rare disorder characterized by impaired ventricular
filling with decreased diastolic volume. We are reporting the functional effects of the first …

Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …

Myocyte disarray is a hallmark of many cardiac disorders. However, the relationship
between alterations in the orientation of individual myofibrils and myofilaments to disease …

Key points Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2)
caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy…