Cancer cells consume glucose and secrete lactate in culture. It is unknown whether lactate
contributes to energy metabolism in living tumors. We previously reported that human non-…

Non-small cell lung cancer (NSCLC) is heterogeneous in the genetic and environmental
parameters that influence cell metabolism in culture. Here, we assessed the impact of these …

A comprehensive cellular anatomy of normal human prostate is essential for solving the
cellular origins of benign prostatic hyperplasia and prostate cancer. The tools used to analyze …

Heterozygous mutations in four telomere-related genes have been linked to pulmonary
fibrosis, but little is known about similarities or differences of affected individuals. 115 patients …

Background Patients with hypersensitivity pneumonitis are at risk of developing pulmonary
fibrosis, which is associated with reduced survival. In families with multiple affected members, …

During antibacterial autophagy, ubiquitination of intracellular bacteria recruits proteins that
mediate bacterial delivery to the lysosome for degradation. Smurf1 is an E3 ubiquitin ligase …

Progress toward the understanding and management of human colon cancer can be
significantly advanced if appropriate experimental platforms become available. We have …

By leveraging tumorgraft (patient-derived xenograft) RNA-sequencing data, we developed
an empirical approach, DisHet, to dissect the tumor microenvironment (eTME). We found that …

Leukocyte telomere length (LTL), MUC5B rs35705950 and TOLLIP rs5743890 have been
associated with idiopathic pulmonary fibrosis (IPF). In this observational cohort study, we …

The success of liver grafts is currently limited by the length of time organs are cold preserved
before transplant. Novel insights to improve viability of cold-stored organs may emerge from …