By removing biosynthetic errors from newly synthesized DNA, mismatch repair (MMR) improves
the fidelity of DNA replication by several orders of magnitude. Loss of MMR brings about …

In addition to its well-documented effects on gene silencing, cytosine methylation is a
prominent cause of mutations. In humans, the mutation rate from 5-methylcytosine (m 5 C) to …

DNA mismatch recognition and binding in human cells has been thought to be mediated by
the hMSH2 protein. Here it is shown that the mismatch-binding factor consists of two distinct …

Colorectal cancers are believed to arise predominantly from adenomas. Although these
precancerous lesions have been subjected to extensive clinical, pathologic, and molecular …

Postreplicative mismatch repair (MMR) increases the fidelity of DNA replication by up to three
orders of magnitude, through correcting DNA polymerase errors that escaped proofreading…

The molecular defects responsible for tumor cell hypermutability in humans have not yet
been fully identified. Here the gene encoding a G/T mismatch-binding protein (GTBP) was …

Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG)
superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired with …

In human cells, mismatch recognition is mediated by a heterodimeric complex, hMutSα,
comprised of two members of the MutS homolog (MSH) family of proteins, hMSH2 and GTBP [1,2]…

The mismatch repair (MMR) system detects non-Watson–Crick base pairs and strand
misalignments arising during DNA replication and mediates their removal by catalyzing excision of …

DNA glycosylases initiate base excision repair (BER) through the generation of potentially
harmful abasic sites (AP sites) in DNA. Human thymine‐DNA glycosylase (TDG) is a mismatch…