MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced
by Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …

Retrotransposons are “copy-and-paste” insertional mutagens that substantially contribute to
mammalian genome content. Retrotransposons often carry long terminal repeats (LTRs) for …

Recruitment of appropriate RNA processing factors to the site of transcription is controlled
by post-translational modifications of the C-terminal domain (CTD) of RNA polymerase II (…

Uridylation of various cellular RNA species at the 3′ end has been generally linked to RNA
degradation. In mammals, uridylated pre‐let‐7 miRNAs and mRNAs are targeted by the 3′ …

While type I interferon (IFN) is best known for its key role against viral infection, accumulating
preclinical and clinical data indicate that robust type I IFN production in the tumor …

Purpose: The successful implementation of immune checkpoint inhibitors (ICI) in the clinical
management of various solid tumors has raised considerable expectations for patients with …

PIWI-interacting RNAs (piRNAs) support the germline by suppressing retrotransposons.
Studies of the pathway in mice have strongly shaped the view that mammalian piRNAs are …

We report over 30 μs of unrestrained molecular dynamics simulations of six protein–RNA
complexes in explicit solvent. We utilize the AMBER ff99bsc0χ OL3 RNA force field combined …

The Nuclear Exosome Targeting (NEXT) complex is a key cofactor of the mammalian nuclear
exosome in the removal of Promoter Upstream Transcripts (PROMPTs) and potentially …

Dendritic cells (DCs) have received considerable attention as potential targets for the
development of novel cancer immunotherapies. However, the clinical efficacy of DC-based …