Therapeutics utilizing siRNA are currently limited by the availability of safe and effective delivery
systems. Cutaneous diseases, specifically ones with significant genetic components are …

Engineered proteins provide an interesting template for designing fluorine-19 ( 19 F)
magnetic resonance imaging (MRI) contrast agents, yet progress has been hindered by the …

We describe the design and characterization of fluorinated coiled-coil proteins able to assemble
into robust nano- and microfibers. Fluorination is achieved biosynthetically by residue-…

A lipoproteoplex comprised of an engineered supercharged coiled-coil protein (CSP) bearing
multiple arginines and the cationic lipid formulation FuGENE HD (FG) was developed for …

An engineered supercharged coiled-coil protein (CSP) and the cationic transfection reagent
Lipofectamine 2000 are combined to form a lipoproteoplex for the purpose of dual delivery …

From a relatively limited selection of base materials, nature has steered the development of
truly remarkable materials. The simplest and often overlooked organisms have demonstrated …

Short interfering RNA (siRNA) therapeutics have soared in popularity due to their highly
selective and potent targeting of faulty genes, providing a non‐palliative approach to address …

Over the course of evolution, nature has made extensive use of the α-helical coiledcoil for a
wide breadth of applications in gene regulation, mitosis, cellular and muscular motility as …

Gene therapy has the potential to treat various diseases and has recently gained new
interest due to the deployment nucleic acid based vaccines for COVID-19. Despite these …

PURPOSE: Dermal penetration, drug degradation/toxicity, and non-specific effects are
challenges in implementation of topical drug delivery systems. Here, we examine a new topical …