Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue function
at the cellular level, yet studies analyzing healthy adult human small intestine and colon …

Two-dimensional (2D) cultures of intestinal and colonic epithelium can be generated using
human intestinal stem cells (hISCs) derived from primary tissue sources. These 2D cultures …

In 1900, Adami speculated that a sequence of context‐independent energetic and structural
changes governed the reversion of differentiated cells to a proliferative, regenerative state. …

The number of studies investigating the human gastrointestinal tract using various single-cell
profiling methods has increased substantially in the past few years. Although this increase …

… Joseph Burclaff was responsible for data acquisition, analysis and interpretation, and
critical revision of the manuscript. Spencer G. Willet was responsible for data acquisition and …

Background & Aims Adult zymogen-producing (zymogenic) chief cells (ZCs) in the mammalian
gastric gland base are believed to arise from descending mucous neck cells, which arise …

Cre/loxP technology has been widely used to study cell type-specific functions of genes.
Proper interpretation of such data critically depends on a clear understanding of the tissue …

Differentiated cells can re-enter the cell cycle to repair tissue damage via a series of discrete
morphological and molecular stages coordinated by the cellular energetics regulator …

The gut epithelium has a remarkable ability to recover from damage. We employed a combination
of high-throughput sequencing approaches, mouse genetics, and murine and human …

Cellular metabolism plays important functions in dictating stem cell behaviors, although its
role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that …