Single-cell RNA sequencing (scRNA-seq) enables the systematic identification of cell
populations in a tissue, but characterizing their spatial organization remains challenging. We …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). There is a dire need for novel effective antivirals to …

Tissue-resident macrophages are a diverse population of cells that perform specialized
functions including sustaining tissue homeostasis and tissue surveillance. Here, we report an …

Free-living mammals, such as humans and wild mice, display heightened immune activation
compared with artificially maintained laboratory mice. These differences are partially …

Epidemiological evidence supports a direct association between early microbiota impact—including
C-section—and obesity. We performed antibiotic-free, fostered C-sections and …

Early-life antibiotic exposure perturbs the intestinal microbiota and accelerates type 1
diabetes (T1D) development in the NOD mouse model. Here, we found that maternal cecal …

Over-accumulation of oxalate in humans may lead to nephrolithiasis and nephrocalcinosis.
Humans lack endogenous oxalate degradation pathways (ODP), but intestinal microbes can …

The relative contributions of genetic and environmental factors to variation in immune
responses are poorly understood. Here, we performed a phenotypic analysis of immunological …

Staphylococcus aureus is an opportunistic pathogen and chief among bloodstream-infecting
bacteria. S. aureus produces an array of human-specific virulence factors that may …

… Author links open overlay panel Joseph C. Devlin 1 2 3 ∗ , Jordan Axelrad 4 ∗ , Ashley M.
Hine 1 4 ∗ , Shannon Chang 4 , Suparna Sarkar 5 , Jian-Da Lin 1 8 9 , Kelly V. Ruggles 3 7 , …