[HTML][HTML] Germline de novo mutations in families with Mendelian cancer syndromes caused by defects in DNA repair
DNA repair defects underlie many cancer syndromes. We tested whether de novo germline
mutations (DNMs) are increased in families with germline defects in polymerase …
mutations (DNMs) are increased in families with germline defects in polymerase …
[HTML][HTML] Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways
…, S Gold, L Lasecka-Dykes, C Wright, JC Ward… - PLoS …, 2017 - journals.plos.org
The RNA genomes of picornaviruses are translated into single polyproteins which are
subsequently cleaved into structural and non-structural protein products. For genetic economy, …
subsequently cleaved into structural and non-structural protein products. For genetic economy, …
Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand
Genome replication of positive strand RNA viruses requires the production of a complementary
negative strand RNA that serves as a template for synthesis of more positive strand …
negative strand RNA that serves as a template for synthesis of more positive strand …
[HTML][HTML] Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication
The genomes of positive-sense RNA viruses encode polyproteins that are essential for
mediating viral replication. These viral polyproteins must undergo proteolysis (also termed …
mediating viral replication. These viral polyproteins must undergo proteolysis (also termed …
Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication
Probing the molecular interactions within the foot-and-mouth disease virus (FMDV) RNA
replication complex has been restricted in part by the lack of suitable reagents. Random …
replication complex has been restricted in part by the lack of suitable reagents. Random …
Both cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication
…, C Ferrer-Orta, EA Loundras, JC Ward… - Journal of …, 2016 - Am Soc Microbiol
The Picornaviridae is a large family of positive-sense RNA viruses that contains numerous
human and animal pathogens, including foot-and-mouth disease virus (FMDV). The …
human and animal pathogens, including foot-and-mouth disease virus (FMDV). The …
[HTML][HTML] Functional advantages of triplication of the 3B coding region of the FMDV genome
For gene duplication to be maintained, particularly in the small genomes of RNA viruses,
this should offer some advantages. We have investigated the functions of a small protein …
this should offer some advantages. We have investigated the functions of a small protein …
Involvement of a nonstructural protein in poliovirus capsid assembly
Virus capsid proteins must perform a number of roles. These include self-assembly and
maintaining stability under challenging environmental conditions, while retaining the …
maintaining stability under challenging environmental conditions, while retaining the …
[HTML][HTML] The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus
JC Ward, L Lasecka-Dykes, C Neil, OO Adeyemi… - PLoS …, 2022 - journals.plos.org
Non-coding regions of viral RNA (vRNA) genomes are critically important in the regulation
of gene expression. In particular, pseudoknot (PK) structures, which are present in a wide …
of gene expression. In particular, pseudoknot (PK) structures, which are present in a wide …
Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon
Hepatitis C virus (HCV) is an important human pathogen causing 400 000 chronic liver
disease-related deaths annually. Until recently, the majority of laboratory-based investigations …
disease-related deaths annually. Until recently, the majority of laboratory-based investigations …