Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
JH Taube, JI Herschkowitz… - Proceedings of the …, 2010 - National Acad Sciences
The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive,
migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to …
migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to …
FOXC2 expression links epithelial–mesenchymal transition and stem cell properties in breast cancer
…, AA Tinnirello, SJ Werden, KW Evans, JH Taube… - Cancer research, 2013 - AACR
Resistance to chemotherapy and metastases are the major causes of breast cancer-related
mortality. Moreover, cancer stem cells (CSC) play critical roles in cancer progression and …
mortality. Moreover, cancer stem cells (CSC) play critical roles in cancer progression and …
[HTML][HTML] Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
The epithelial-mesenchymal transition (EMT) imparts metastatic competence on otherwise
non-metastatic cancer cells through decreased inter-cellular adhesions, increased migratory …
non-metastatic cancer cells through decreased inter-cellular adhesions, increased migratory …
[HTML][HTML] GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer
Background Triple-negative breast cancers (TNBCs), which lack receptors for estrogen,
progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. …
progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. …
GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer
The epithelial–mesenchymal transition (EMT) bestows cancer cells with increased stem cell
properties and metastatic potential. To date, multiple extracellular stimuli and transcription …
properties and metastatic potential. To date, multiple extracellular stimuli and transcription …
[HTML][HTML] Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition
Background Epithelial-mesenchymal transition (EMT) is known to impart metastasis and
stemness characteristics in breast cancer. To characterize the epigenetic reprogramming …
stemness characteristics in breast cancer. To characterize the epigenetic reprogramming …
[HTML][HTML] Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein
In this manuscript, we use genetic data to provide a three-faceted analysis on the links between
molecular subclasses of glioblastoma, epithelial-to-mesenchymal transition (EMT) and …
molecular subclasses of glioblastoma, epithelial-to-mesenchymal transition (EMT) and …
Synthesis and characterization of nanometer-sized liposomes for encapsulation and microRNA transfer to breast cancer cells
Introduction: The use of liposomes as a drug delivery carrier (DDC) for the treatment of
various diseases, especially cancer, is rapidly increasing, requiring more stringent synthesis, …
various diseases, especially cancer, is rapidly increasing, requiring more stringent synthesis, …
[HTML][HTML] Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells
Epigenetic control of genes that are silent in embryonic stem cells, but destined for expression
during differentiation, includes distinctive hallmarks, such as simultaneous activating/…
during differentiation, includes distinctive hallmarks, such as simultaneous activating/…
[HTML][HTML] The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal …
…, KS Johnson, KN Reisenauer, TA Nesbit, R Joseph… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The deposition of the activating H3K4me3 and repressive H3K27me3 histone modifications
within the same promoter, forming a so-called bivalent domain, maintains gene expression …
within the same promoter, forming a so-called bivalent domain, maintains gene expression …