Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene
regulation that have a major impact on many diseases and provide an exciting avenue toward …

Biomolecular condensates formed by phase separation can compartmentalize and regulate
cellular processes 1 , 2 . Emerging evidence has suggested that membraneless subcellular …

Herpes simplex virus 1 (HSV-1) hijacks ubiquitination machinery to modify the cellular proteome
to create an environment permissive for virus replication. HSV-1 encodes its own RING-…

Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-19
patients, but the timing and organs affected vary among reports. Here, we reveal the …

Folds are the basic building blocks of protein structures. Understanding the emergence of
novel protein folds is an important step towards understanding the rules governing the …

Intrinsic antiviral host factors confer cellular defence by limiting virus replication and are
often counteracted by viral countermeasures. We reasoned that host factors that inhibit viral …

Viruses promote infection by hijacking the ubiquitin machinery of the host to counteract or
redirect cellular processes. Adenovirus encodes two early proteins, E1B55K and E4orf6, that …

Foxp3 + T regulatory (T reg ) cells suppress immune cell activation and establish normal
immune homeostasis. How T reg cells maintain their identity is not completely understood. Here …

The capacity for T cells to become activated and clonally expand during pathogen invasion
is pivotal for protective immunity. Our understanding of how T cell receptor (TCR) signaling …