Single-domain Variable New Antigen Receptors (VNARs) from the immune system of sharks
are the smallest naturally occurring binding domains found in nature. Possessing flexible …

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) is a lethal, heterogeneous
disease with few therapeutic strategies that significantly prolong survival. Innovative …

Purpose: Aggressive variant prostate cancer (AVPC) is a nonandrogen receptor–driven form
of disease that arises in men in whom standard-of-care therapies have failed. Therapeutic …

Combating the COVID-19 pandemic requires potent and low-cost therapeutics. We identified
a novel series of single-domain antibodies (ie, nanobody), Nanosota-1, from a camelid …

The Mesenchymal Epithelial Transition (MET) receptor tyrosine kinase is upregulated or
mutated in 5% of non-small-cell lung cancer (NSCLC) patients and overexpressed in multiple …

Rational drug design creates innovative therapeutics based on knowledge of the biological
target to provide more effective and responsible therapeutics. Chagas disease, endemic …

Background Observational studies have suggested that accelerated surgery is associated
with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed …

Adeno-associated virus has been remarkably successful in the clinic, but its broad tropism is
a practical limitation of precision gene therapy. A promising path to engineer AAV tropism is …

Acute kidney injury (AKI) is a lesser-known complication of hip fracture that may come about
owing to decreased kidney perfusion and heightened inflammation from trauma, pain, …

The insulin-like growth factor-1 receptor (IGF-1R) plays an important role in the regulation of
cell growth and differentiation, and in protection from apoptosis. IGF-1R has been shown to …