ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
…, KK Gamage, R Kirchner, R Moccia… - Nature …, 2019 - nature.com
The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene …
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene …
A defined glycosaminoglycan-binding substratum for human pluripotent stem cells
JR Klim, L Li, PJ Wrighton, MS Piekarczyk… - Nature …, 2010 - nature.com
To exploit the full potential of human pluripotent stem cells for regenerative medicine,
developmental biology and drug discovery, defined culture conditions are needed. Media of known …
developmental biology and drug discovery, defined culture conditions are needed. Media of known …
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
…, LI Bruijn, S Chandran, K Eggan, R Ho, JR Klim… - Nature …, 2016 - nature.com
Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However, …
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However, …
[PDF][PDF] Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection
Zika virus (ZIKV) can cross the placental barrier, resulting in infection of the fetal brain and
neurological defects including microcephaly. The cellular tropism of ZIKV and the identity of …
neurological defects including microcephaly. The cellular tropism of ZIKV and the identity of …
How to make spinal motor neurons
BN Davis-Dusenbery, LA Williams, JR Klim… - …, 2014 - journals.biologists.com
All muscle movements, including breathing, walking, and fine motor skills rely on the function
of the spinal motor neuron to transmit signals from the brain to individual muscle groups. …
of the spinal motor neuron to transmit signals from the brain to individual muscle groups. …
[PDF][PDF] Loss of mouse Stmn2 function causes motor neuropathy
…, F Limone, AB Dorr, A Couto, G Pintacuda, BJ Joseph… - Neuron, 2022 - cell.com
Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration accompanied
by aberrant accumulation and loss of function of the RNA-binding protein TDP43. Thus …
by aberrant accumulation and loss of function of the RNA-binding protein TDP43. Thus …
High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells
Synthetic materials that promote the growth or differentiation of cells have advanced the fields
of tissue engineering and regenerative medicine. Most functional biomaterials are based …
of tissue engineering and regenerative medicine. Most functional biomaterials are based …
[PDF][PDF] Reactive astrocytes promote ALS-like degeneration and intracellular protein aggregation in human motor neurons by disrupting autophagy through TGF-β1
P Tripathi, N Rodriguez-Muela, JR Klim, AS de Boer… - Stem cell reports, 2017 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease.
Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS. …
Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS. …
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated
exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant …
exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant …
Connecting TDP-43 pathology with neuropathy
JR Klim, G Pintacuda, LA Nash, IG San Juan… - Trends in …, 2021 - cell.com
Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-binding
protein, is a primary component of insoluble aggregates associated with several …
protein, is a primary component of insoluble aggregates associated with several …