The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene …

To exploit the full potential of human pluripotent stem cells for regenerative medicine,
developmental biology and drug discovery, defined culture conditions are needed. Media of known …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However, …

Zika virus (ZIKV) can cross the placental barrier, resulting in infection of the fetal brain and
neurological defects including microcephaly. The cellular tropism of ZIKV and the identity of …

All muscle movements, including breathing, walking, and fine motor skills rely on the function
of the spinal motor neuron to transmit signals from the brain to individual muscle groups. …

Amyotrophic lateral sclerosis (ALS) is characterized by motor neuron degeneration accompanied
by aberrant accumulation and loss of function of the RNA-binding protein TDP43. Thus …

Synthetic materials that promote the growth or differentiation of cells have advanced the fields
of tissue engineering and regenerative medicine. Most functional biomaterials are based …

Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing motor neuron disease.
Astrocytic factors are known to contribute to motor neuron degeneration and death in ALS. …

To discover novel genes underlying amyotrophic lateral sclerosis (ALS), we aggregated
exomes from 3,864 cases and 7,839 ancestry-matched controls. We observed a significant …

Transactive response DNA-binding protein 43 kDa (TDP-43), a multifunctional nucleic acid-binding
protein, is a primary component of insoluble aggregates associated with several …