[HTML][HTML] Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
BJ Hulme, KK Geyer, JE Forde-Thomas… - PLoS …, 2022 - journals.plos.org
α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl
hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on …
hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on …
Antischistosomal properties of sclareol and its heck-coupled derivatives: design, synthesis, biological evaluation, and untargeted metabolomics
…, H Whiteland, R Baptista, JE Forde-Thomas… - ACS Infectious …, 2019 - ACS Publications
Sclareol, a plant-derived diterpenoid widely used as a fragrance and flavoring substance, is
well-known for its promising antimicrobial and anticancer properties. However, its activity on …
well-known for its promising antimicrobial and anticancer properties. However, its activity on …
[HTML][HTML] An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola …
HL Whiteland, A Chakroborty, JE Forde-Thomas… - International Journal for …, 2018 - Elsevier
Two economically and biomedically important platyhelminth species, Fasciola hepatica (liver
fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical …
fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical …
[HTML][HTML] The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
…, BJ Hulme, IW Chalmers, J Forde-Thomas… - PLoS Neglected …, 2019 - journals.plos.org
Background Praziquantel represents the frontline chemotherapy used to treat schistosomiasis,
a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke …
a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke …
[HTML][HTML] Using ChEMBL to complement schistosome drug discovery
G Padalino, A Coghlan, G Pagliuca, JE Forde-Thomas… - Pharmaceutics, 2023 - mdpi.com
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective
vaccine is registered for use, the cornerstone of schistosomiasis control remains …
vaccine is registered for use, the cornerstone of schistosomiasis control remains …
[HTML][HTML] Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
…, RE Barnes, E Sayers, J Forde-Thomas… - European Journal of …, 2021 - Elsevier
Schistosomiasis is a neglected disease of poverty that is caused by infection with blood
fluke species contained within the genus Schistosoma. For the last 40 years, control of …
fluke species contained within the genus Schistosoma. For the last 40 years, control of …
Structural Requirements for dihydrobenzoxazepinone anthelmintics: Actions against medically important and model parasites: Trichuris muris, Brugia malayi …
…, R Forman, AE Marriott, J Forde-Thomas… - ACS Infectious …, 2021 - ACS Publications
Nine hundred million people are infected with the soil-transmitted helminths Ascaris
lumbricoides (roundworm), hookworm, and Trichuris trichiura (whipworm). However, low single-…
lumbricoides (roundworm), hookworm, and Trichuris trichiura (whipworm). However, low single-…
Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development
…, G Padalino, AKN Chan, J Forde-Thomas… - Journal of Medicinal …, 2023 - ACS Publications
Schistosomiasis is a disease affecting >200 million people worldwide, but its treatment relies
on a single agent, praziquantel. To investigate new avenues for schistosomiasis control, we …
on a single agent, praziquantel. To investigate new avenues for schistosomiasis control, we …
[HTML][HTML] Plasmacytoid dendritic cells facilitate Th cell cytokine responses throughout Schistosoma mansoni infection
…, SL Brown, RJ Lundie, J Forde-Thomas… - …, 2021 - journals.aai.org
Plasmacytoid dendritic cells (pDCs) are potent producers of type I IFN (IFN-I) during viral
infection and respond to IFN-I in a positive feedback loop that promotes their function. IFN-I …
infection and respond to IFN-I in a positive feedback loop that promotes their function. IFN-I …
[HTML][HTML] Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of …
…, G Padalino, JE Forde-Thomas… - PLoS Neglected …, 2021 - journals.plos.org
Extracellular Vesicles (EVs) are an integral component of cellular/organismal communication
and have been found in the excreted/secreted (ES) products of both protozoan and …
and have been found in the excreted/secreted (ES) products of both protozoan and …