User profiles for Joshua B. Singer
 | Joshua B. SingerMRC-University of Glasgow Centre for Virus Research Verified email at glasgow.ac.uk Cited by 957 |
[HTML][HTML] Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen
Virus host shifts are generally associated with novel adaptations to exploit the cells of the
new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (…
new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (…
[HTML][HTML] Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
The host innate immune response mediated by type I interferon (IFN) and the resulting up-regulation
of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to …
of hundreds of interferon-stimulated genes (ISGs) provide an immediate barrier to …
Computational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research
…, DL Robertson, S Sadegh, JB Singer… - Briefings in …, 2021 - academic.oup.com
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the
family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of …
family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of …
[HTML][HTML] Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland
…, S Rooke, S Shaaban, R Shah, JB Singer… - Nature …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) was first diagnosed in Scotland on 1 March 2020.
During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital …
During the first month of the outbreak, 2,641 cases of COVID-19 led to 1,832 hospital …
No evidence for distinct types in the evolution of SARS-CoV-2
… Joshua B Singer , Joshua B Singer … Oscar A MacLean, Richard J Orton, Joshua B Singer,
David L Robertson, No evidence for distinct types in the evolution of SARS-CoV-2, Virus …
David L Robertson, No evidence for distinct types in the evolution of SARS-CoV-2, Virus …
[HTML][HTML] GLUE: a flexible software system for virus sequence data
Background Virus genome sequences, generated in ever-higher volumes, can provide new
scientific insights and inform our responses to epidemics and outbreaks. To facilitate …
scientific insights and inform our responses to epidemics and outbreaks. To facilitate …
Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data
…, A Keeley, BB Lindsey, A Marek, C Peters, JB Singer… - Elife, 2021 - elifesciences.org
Background: Rapid identification and investigation of healthcare-associated infections (HCAIs)
is important for suppression of SARS-CoV-2, but the infection source for hospital onset …
is important for suppression of SARS-CoV-2, but the infection source for hospital onset …
[HTML][HTML] Rapid in-country sequencing of whole virus genomes to inform rabies elimination programmes
Genomic surveillance is an important aspect of contemporary disease management but has
yet to be used routinely to monitor endemic disease transmission and control in low-and …
yet to be used routinely to monitor endemic disease transmission and control in low-and …
[PDF][PDF] Highly diverse Hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments
The global plan to eradicate hepatitis C virus (HCV) led by the World Health Organization
outlines the use of highly effective direct‐acting antiviral drugs (DAAs) to achieve elimination …
outlines the use of highly effective direct‐acting antiviral drugs (DAAs) to achieve elimination …
Real world SOF/VEL/VOX retreatment outcomes and viral resistance analysis for HCV patients with prior failure to DAA therapy
…, CF Manso, DF Bibby, JB Singer… - Journal of Viral …, 2021 - Wiley Online Library
Sustained viral response (SVR) rates for direct‐acting antiviral (DAA) therapy for hepatitis C
virus (HCV) infection routinely exceed 95%. However, a small number of patients require …
virus (HCV) infection routinely exceed 95%. However, a small number of patients require …