User profiles for Joshua Berke

Josh Berke

Professor of Neurology and Psychiatry, UCSF
Verified email at ucsf.edu
Cited by 11961

Dissociable dopamine dynamics for learning and motivation

…, LT Vinson, T Patriarchi, L Tian, RT Kennedy, JD Berke - Nature, 2019 - nature.com
The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is
critical for motivation to work for rewards and reward-driven learning. How dopamine …

Mesolimbic dopamine signals the value of work

…, RT Kennedy, BJ Aragona, JD Berke - Nature …, 2016 - nature.com
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …

Canceling actions involves a race between basal ganglia pathways

…, DK Leventhal, N Mallet, F Chen, JD Berke - Nature …, 2013 - nature.com
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that
fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested …

An expanded palette of dopamine sensors for multiplex imaging in vivo

…, CM Davis, B Wiltgen, M von Zastrow, JD Berke… - Nature …, 2020 - nature.com
Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP-…

What does dopamine mean?

JD Berke - Nature neuroscience, 2018 - nature.com
Dopamine is a critical modulator of both learning and motivation. This presents a problem:
how can target cells know whether increased dopamine is a signal to learn or to move? It is …

[HTML][HTML] Dopamine subsystems that track internal states

…, N Sivakumar, JS Ahn, TV Corpuz, JD Berke… - Nature, 2022 - nature.com
Food and water are rewarding in part because they satisfy our internal needs 1 , 2 . Dopaminergic
neurons in the ventral tegmental area (VTA) are activated by gustatory rewards 3 , 4 – …

[PDF][PDF] Addiction, dopamine, and the molecular mechanisms of memory

JD Berke, SE Hyman - Neuron, 2000 - cell.com
Joshua D. Berke* § and Steven E. Hyman*†‡* Section on Molecular Plasticity National
Institute of Neurological Disorders and Stroke locomotor activity. Psychostimulants also tend to …

[PDF][PDF] Acute effects of cocaine on human brain activity and emotion

…, RM Weisskoff, DN Kennedy, N Makris, JD Berke… - Neuron, 1997 - cell.com
We investigated brain circuitry mediating cocaine- induced euphoria and craving using
functional MRI (fMRI). During double-blind cocaine (0.6 mg/kg) and saline infusions in cocaine-…

[PDF][PDF] Oscillatory entrainment of striatal neurons in freely moving rats

JD Berke, M Okatan, J Skurski, HB Eichenbaum - Neuron, 2004 - cell.com
Oscillations and synchrony in basal ganglia circuits may play a key role in the organization
of voluntary actions and habits. We recorded single units and local field potentials from …

[HTML][HTML] Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats

C Chang, JD Berke, S Maren - PLoS one, 2010 - journals.plos.org
Delivering extinction trials minutes after fear conditioning yields only a short-term fear
suppression that fully recovers the following day. Because extinction has been reported to …