User profiles for Joshua Berke
Josh BerkeProfessor of Neurology and Psychiatry, UCSF Verified email at ucsf.edu Cited by 11961 |
Dissociable dopamine dynamics for learning and motivation
The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is
critical for motivation to work for rewards and reward-driven learning. How dopamine …
critical for motivation to work for rewards and reward-driven learning. How dopamine …
Mesolimbic dopamine signals the value of work
…, RT Kennedy, BJ Aragona, JD Berke - Nature …, 2016 - nature.com
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating …
Canceling actions involves a race between basal ganglia pathways
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that
fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested …
fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested …
An expanded palette of dopamine sensors for multiplex imaging in vivo
Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP-…
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP-…
What does dopamine mean?
JD Berke - Nature neuroscience, 2018 - nature.com
Dopamine is a critical modulator of both learning and motivation. This presents a problem:
how can target cells know whether increased dopamine is a signal to learn or to move? It is …
how can target cells know whether increased dopamine is a signal to learn or to move? It is …
[HTML][HTML] Dopamine subsystems that track internal states
Food and water are rewarding in part because they satisfy our internal needs 1 , 2 . Dopaminergic
neurons in the ventral tegmental area (VTA) are activated by gustatory rewards 3 , 4 – …
neurons in the ventral tegmental area (VTA) are activated by gustatory rewards 3 , 4 – …
[PDF][PDF] Addiction, dopamine, and the molecular mechanisms of memory
Joshua D. Berke* § and Steven E. Hyman*†‡* Section on Molecular Plasticity National
Institute of Neurological Disorders and Stroke locomotor activity. Psychostimulants also tend to …
Institute of Neurological Disorders and Stroke locomotor activity. Psychostimulants also tend to …
[PDF][PDF] Acute effects of cocaine on human brain activity and emotion
We investigated brain circuitry mediating cocaine- induced euphoria and craving using
functional MRI (fMRI). During double-blind cocaine (0.6 mg/kg) and saline infusions in cocaine-…
functional MRI (fMRI). During double-blind cocaine (0.6 mg/kg) and saline infusions in cocaine-…
[PDF][PDF] Oscillatory entrainment of striatal neurons in freely moving rats
Oscillations and synchrony in basal ganglia circuits may play a key role in the organization
of voluntary actions and habits. We recorded single units and local field potentials from …
of voluntary actions and habits. We recorded single units and local field potentials from …
[HTML][HTML] Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats
Delivering extinction trials minutes after fear conditioning yields only a short-term fear
suppression that fully recovers the following day. Because extinction has been reported to …
suppression that fully recovers the following day. Because extinction has been reported to …