Precise regulation of the formation, maintenance, and remodeling of the vasculature is required
for normal development, tissue response to injury, and tumor progression. How specific …

Vascular proliferative diseases such as atherosclerosis and coronary restenosis are leading
causes of morbidity and mortality in developed nations. Common features associated with …

The angiogenic sprout has been compared to the growing axon, and indeed, many proteins
direct pathfinding by both structures 1 . The Roundabout (Robo) proteins are guidance …

Background Sporadic arteriovenous malformations of the brain, which are morphologically
abnormal connections between arteries and veins in the brain vasculature, are a leading …

10.7554/eLife.03848.001 Mammalian heart development requires precise allocation of
cardiac progenitors. The existence of a multipotent progenitor for all anatomic and cellular …

Members of the Slit family of secreted ligands interact with Roundabout (Robo) receptors to
provide guidance cues for many cell types. For example, Slit/Robo signaling elicits repulsion …

The formation of a hierarchical vascular network, composed of arteries, veins, and capillaries,
is essential for embryogenesis and is required for the production of new functional …

The lung microvasculature is essential for gas exchange and commonly considered
homogeneous. We show that VEGFA from the epithelium is required for a distinct endothelial cell (…

During development, progenitors progress through transition states. The cardiac epicardium
contains progenitors of essential non-cardiomyocytes. The Hippo pathway, a kinase …

Vegf signaling specifies arterial fate during early vascular development by inducing the
transcription of Delta-like 4 (Dll4), the earliest Notch ligand gene expressed in arterial precursor …