We present a DNA library preparation method that has allowed us to reconstruct a high-coverage
(30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality …

We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …

For 10,000 years pigs and humans have shared a close and complex relationship. From
domestication to modern breeding practices, humans have shaped the genomes of domestic …

Although Neandertal sequences that persist in the genomes of modern humans have been
identified in Eurasians, comparable studies in people whose ancestors hybridized with both …

Traditionally, the process of domestication is assumed to be initiated by humans, involve
few individuals and rely on reproductive isolation between wild and domestic forms. We …

The rich diversity of morphology and behavior displayed across primate species provides
an informative context in which to study the impact of genomic diversity on fundamental …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

As modern humans dispersed from Africa throughout the world, they encountered and interbred
with archaic hominins, including Neanderthals and Denisovans [1, 2]. Although genome-…

The genomes of contemporary humans contain considerable information about the history
of our species. Although the general contours of human evolutionary history have been …

Neanderthals and anatomically modern humans overlapped geographically for a period of
over 30,000 years following human migration out of Africa. During this period, Neanderthals …