An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …

Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex 1 , 2 , yet all derive from neural progenitors of the …

The neural mechanisms and durability of Δ9-tetrahydrocannabinol (THC) impact on threat
processing in humans are not fully understood. Herein, we used functional MRI and …

Individuals vary in their propensity to engage in aggressive behaviors, and recent research
has sought to identify individual differences that contribute to a person’s propensity for …

Objective The nature of interpersonal relationships, whether supportive or critical, may affect
the association between health status and mental health outcomes. We examined the …

Accumulation of fibrillar amyloid β protein in blood vessels of the brain, a condition known
as cerebral amyloid angiopathy (CAA), is a common pathology of elderly individuals, a …

Background Preclinical data suggest that early life stress has detrimental effects on the brain’s
dopaminergic system, particularly the mesocorticolimbic pathway. Altered dopamine …

Cerebral amyloid angiopathy (CAA) is the deposition of amyloid protein in the cerebral
vasculature, a common feature in both aging and Alzheimer’s disease (AD). However, the effects …

Background Cerebral amyloid angiopathy (CAA) is a common cerebral small vessel disease
of the aged and a prominent comorbidity of Alzheimer’s disease (AD). CAA can promote a …

We report the generation of a multimodal cell census and atlas of the mammalian primary
motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (…