[HTML][HTML] The past, present, and future of a human T-cell leukemia virus type 1 vaccine
JJ Tu, V Maksimova, L Ratner, AR Panfil - Frontiers in Microbiology, 2022 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus which causes
a lifelong infection. An estimated 5–10 million persons are infected with HTLV-1 worldwide …
a lifelong infection. An estimated 5–10 million persons are infected with HTLV-1 worldwide …
[PDF][PDF] A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization
…, KE Burgomaster, S Zhang, JF Mangold, JJ Tu… - Cell, 2022 - cell.com
Congenital Zika virus (ZIKV) infection results in neurodevelopmental deficits in up to 14% of
infants born to ZIKV-infected mothers. Neutralizing antibodies are a critical component of …
infants born to ZIKV-infected mothers. Neutralizing antibodies are a critical component of …
[PDF][PDF] Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells
Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill
patients and require intravenous infusions, with limited options for exposed or infected …
patients and require intravenous infusions, with limited options for exposed or infected …
Maternal broadly neutralizing antibodies can select for neutralization-resistant, infant-transmitted/founder HIV variants
… Martinez led the initial phases of the project and completed the majority of the experiments
to test the original hypothesis, and Joshua J. Tu led the second-phase experiments for …
to test the original hypothesis, and Joshua J. Tu led the second-phase experiments for …
[HTML][HTML] E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2
…, DM Brass, AE Nagler, D Carmack, JJ Tu… - Cell Death …, 2022 - nature.com
Diacetyl (DA) is an α-diketone that is used to flavor microwave popcorn, coffee, and e-cigarettes.
Occupational exposure to high levels of DA causes impaired lung function and …
Occupational exposure to high levels of DA causes impaired lung function and …
[HTML][HTML] Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection
…, CS Nelson, JJ Tu, JF Mangold, S Valencia, J Pollara… - Virology, 2020 - Elsevier
Human cytomegalovirus (HCMV) is the most common congenital infection. A glycoprotein B
(gB) subunit vaccine (gB/MF59) is the most efficacious clinically tested to date, having …
(gB) subunit vaccine (gB/MF59) is the most efficacious clinically tested to date, having …
An HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits
JJ Tu, E King, V Maksimova, S Smith, R Macias… - Journal of …, 2024 - Am Soc Microbiol
mRNA vaccine technology has proven to be a viable approach for effectively triggering
immune responses that protect against or limit viral infections and disease. In our study, we …
immune responses that protect against or limit viral infections and disease. In our study, we …
Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses
Despite the worldwide availability of antiretroviral therapy (ART), approximately 150,000
pediatric HIV infections continue to occur annually. ART can dramatically reduce HIV mother-to-…
pediatric HIV infections continue to occur annually. ART can dramatically reduce HIV mother-to-…
[HTML][HTML] Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers
…, EE Giorgi, JJ Tu, DR Martinez, J Eudailey… - PLoS …, 2021 - journals.plos.org
Despite considerable reduction of mother-to-child transmission (MTCT) of HIV through use
of maternal and infant antiretroviral therapy (ART), over 150,000 infants continue to become …
of maternal and infant antiretroviral therapy (ART), over 150,000 infants continue to become …
[HTML][HTML] A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus
Cytomegalovirus (CMV) is a leading cause of infant hearing loss and neurodevelopmental
delay, but there are no clinically licensed vaccines to prevent infection, in part due to …
delay, but there are no clinically licensed vaccines to prevent infection, in part due to …