[HTML][HTML] The past, present, and future of a human T-cell leukemia virus type 1 vaccine

JJ Tu, V Maksimova, L Ratner, AR Panfil - Frontiers in Microbiology, 2022 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus which causes
a lifelong infection. An estimated 5–10 million persons are infected with HTLV-1 worldwide …

[PDF][PDF] A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization

…, KE Burgomaster, S Zhang, JF Mangold, JJ Tu… - Cell, 2022 - cell.com
Congenital Zika virus (ZIKV) infection results in neurodevelopmental deficits in up to 14% of
infants born to ZIKV-infected mothers. Neutralizing antibodies are a critical component of …

[PDF][PDF] Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

R Goswami, VS Russell, JJ Tu, C Thomas, P Hughes… - Iscience, 2021 - cell.com
Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill
patients and require intravenous infusions, with limited options for exposed or infected …

Maternal broadly neutralizing antibodies can select for neutralization-resistant, infant-transmitted/founder HIV variants

DR Martinez, JJ Tu, A Kumar, JF Mangold, RJ Mangan… - MBio, 2020 - Am Soc Microbiol
… Martinez led the initial phases of the project and completed the majority of the experiments
to test the original hypothesis, and Joshua J. Tu led the second-phase experiments for …

[HTML][HTML] E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2

…, DM Brass, AE Nagler, D Carmack, JJ Tu… - Cell Death …, 2022 - nature.com
Diacetyl (DA) is an α-diketone that is used to flavor microwave popcorn, coffee, and e-cigarettes.
Occupational exposure to high levels of DA causes impaired lung function and …

[HTML][HTML] Specificity and effector functions of non-neutralizing gB-specific monoclonal antibodies isolated from healthy individuals with human cytomegalovirus infection

…, CS Nelson, JJ Tu, JF Mangold, S Valencia, J Pollara… - Virology, 2020 - Elsevier
Human cytomegalovirus (HCMV) is the most common congenital infection. A glycoprotein B
(gB) subunit vaccine (gB/MF59) is the most efficacious clinically tested to date, having …

An HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits

JJ Tu, E King, V Maksimova, S Smith, R Macias… - Journal of …, 2024 - Am Soc Microbiol
mRNA vaccine technology has proven to be a viable approach for effectively triggering
immune responses that protect against or limit viral infections and disease. In our study, we …

Vertical HIV-1 transmission in the setting of maternal broad and potent antibody responses

JJ Tu, A Kumar, EE Giorgi, J Eudailey… - Journal of …, 2022 - Am Soc Microbiol
Despite the worldwide availability of antiretroviral therapy (ART), approximately 150,000
pediatric HIV infections continue to occur annually. ART can dramatically reduce HIV mother-to-…

[HTML][HTML] Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers

…, EE Giorgi, JJ Tu, DR Martinez, J Eudailey… - PLoS …, 2021 - journals.plos.org
Despite considerable reduction of mother-to-child transmission (MTCT) of HIV through use
of maternal and infant antiretroviral therapy (ART), over 150,000 infants continue to become …

[HTML][HTML] A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

…, A Kumar, D Wrapp, S Venkatayogi, JJ Tu… - PLoS …, 2023 - journals.plos.org
Cytomegalovirus (CMV) is a leading cause of infant hearing loss and neurodevelopmental
delay, but there are no clinically licensed vaccines to prevent infection, in part due to …