Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and theoretical …

Robustness, the maintenance of a character in the presence of genetic change, can help
preserve adaptive traits but also may hinder evolvability, the ability to bring forth novel …

Cryptic genetic variation can facilitate adaptation in evolving populations. To elucidate the
underlying genetic mechanisms, we used directed evolution in Escherichia coli to accumulate …

The adaptive landscape is an iconic metaphor that pervades evolutionary biology. It was
mostly applied in theoretical models until recent years, when empirical data began to allow …

Robustness is the invariance of a phenotype in the face of environmental or genetic change.
The phenotypes produced by transcriptional regulatory circuits are gene expression …

Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Transition bias, an overabundance of transitions relative to transversions, has been widely
reported among studies of the rates and spectra of spontaneous mutations. However, …

In gene regulatory circuits, the expression of individual genes is commonly modulated by a
set of regulating gene products, which bind to a gene's cis-regulatory region. This region …

We analytically determine when a range of abstract social contagion models permit global
spreading from a single seed on degree-correlated undirected random networks. We deduce …