Introduction In vivo imaging provides a window into the spatially complex, rapidly evolving
physiology of the cell that structural imaging alone cannot. However, observing this …

In many organisms, cortical granules undergo exocytosis following fertilization, releasing
cargo proteins that modify the extracellular covering of the zygote. We identified cortical …

Condensin complexes are essential for mitotic and meiotic chromosome segregation.
Caenorhabditis elegans, like other metazoans, has two distinct mitotic and meiotic condensin …

Although cytokinesis has been intensely studied, the way it is executed during development
is not well understood, despite a long-standing appreciation that various aspects of …

Protein Phosphatase 2A (PP2A) is a heterotrimer composed of scaffolding (A), catalytic (C),
and regulatory (B) subunits. PP2A complexes with B56 subunits are targeted by Shugoshin …

Background During cell division, chromosomes must clear the path of the cleavage furrow
before the onset of cytokinesis. The abscission checkpoint in mammalian cells stabilizes the …

Factors that regulate mitotic spindle positioning remain unclear within the confines of extremely
large embryonic cells, such as the early divisions of the vertebrate embryo, Danio rerio (…

Cell division requires coordinated regulation of chromosome segregation and cytokinesis.
Although much is known about the function of the protease separase in promoting sister …

Ataxin‐2, a conserved RNA‐binding protein, is implicated in the late‐onset neurodegenerative
disease Spinocerebellar ataxia type‐2 (SCA2). SCA2 is characterized by shrunken …

Zinc is a transition metal that displays wide physiological implications ranging from
participation in hundreds of enzymes and proteins to normal growth and development. In the …