Haematopoietic stem cells (HSCs) primarily reside in the bone marrow where signals
generated by stromal cells regulate their self-renewal, proliferation and trafficking. Endosteal …

Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial
strains that drive gut IgA production remain largely unknown. Here, we assessed the IgA-…

Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs).
Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and has a …

Background & aim Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic
fatty liver disease (NAFLD) that is responsible for a growing fraction of cirrhosis and liver …

Endothelial cell (EC) dysfunction is a key feature of multiple organ injury, the primary cause
of fatality seen in critically ill patients. Although the development of EC dysfunction in the …

Background It has been demonstrated in many chronic conditions, including inflammatory
bowel disease (IBD), that better patient knowledge about pathology and treatment improves …

Recent studies demonstrate that gut microbiota regulate tumor response to immune
checkpoint blockade. Still, the mechanisms by which microbiota control tumor response to …

Fecal IgA production depends on colonization by a gut microbiota. However, the bacterial
strains that drive gut IgA production remain largely unknown. By accessing the IgA-inducing …

Abstract 510 Hematopoietic stem cells (HSCs) reside in a specialized microenvironment in
the bone marrow that provides key signals required for HSC maintenance. Neither the …

The human immune system is in constant communication with the commensal microbiota to
significant immune modification in the gut. Still unclear are the regulatory mechanisms that …