Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …

Bariatric surgery is the most effective available treatment for obesity. The most frequently
performed operation, Roux-en-Y gastric bypass (RYGB), causes profound weight loss and …

Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal
hypothalamus (MBH), but the components of this microgliosis and its metabolic consequences …

LIM homeodomain codes regulate the development of many cell types, though it is poorly
understood how these factors control gene expression in a cell-specific manner. Lhx3 is …

OBJECTIVE The hormone fibroblast growth factor 21 (FGF21) exerts diverse, beneficial effects
on energy balance and insulin sensitivity when administered systemically to rodents with …

Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in
peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the …

The arcuate nucleus (ARC) of the hypothalamus plays a key role in sensing metabolic feedback
and regulating energy homeostasis. Recent studies revealed activation of microglia in …

Obesity and its associated metabolic and cardio-vascular disorders are among the most chal-lenging
health problems confronting developed countries. Not only is obesity remarkably …

The brain has emerged as a target for the insulin-sensitizing effects of several hormonal and
nutrient-related signals. The current studies were undertaken to investigate mechanisms …

OBJECTIVE Depletion of body fat stores during uncontrolled, insulin-deficient diabetes (uDM)
results in markedly reduced plasma leptin levels. This study investigated the role of leptin …