SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19
differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not …

Excipients, considered “inactive ingredients,” are a major component of formulated drugs
and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are …

The organic chemist’s toolbox is vast, with technologies to accelerate the synthesis of novel
chemical matter. The field of asymmetric catalysis is one approach to accessing new areas …

Conspectus Computational methods for docking small molecules to proteins are prominent
in drug discovery. There are hundreds, if not thousands, of documented examplesand …

Food and drug products contain diverse and abundant small-molecule additives (excipients)
with unclear impacts on human physiology, drug safety, and response. Here, we evaluate …

The metabolism of xenobioticsand more specifically drugsin the liver is a critical process
controlling their half-life. Although there exist experimental methods, which measure the …

Metalloenzymes are ubiquitous proteins which feature one or more metal ions either directly
involved in the enzymatic activity and/or structural properties (ie, zinc fingers). Several …

The combination of antiestrogens and histone deacetylase inhibitors (HDACi) has been
found to be antiproliferative in breast cancer models. We designed and synthesized hybrid …

Over the years, structure-based design programs and specifically docking small molecules to
proteins have become prominent in drug discovery. However, many of these computational …

Mechanistic-understanding-based selection of excipients may improve formulation development
strategies for generic drug products and potentially accelerate their approval. Our study …