User profiles for Joshua W Shaevitz
Joshua ShaevitzProfessor of Physics and Genomics, Princeton University Verified email at princeton.edu Cited by 10180 |
Mapping the stereotyped behaviour of freely moving fruit flies
…, DM Choi, W Bialek, JW Shaevitz - Journal of The Royal …, 2014 - royalsocietypublishing.org
A frequent assumption in behavioural science is that most of an animal's activities can be
described in terms of a small set of stereotyped motifs. Here, we introduce a method for …
described in terms of a small set of stereotyped motifs. Here, we introduce a method for …
Quantifying behavior to understand the brain
Over the past years, numerous methods have emerged to automate the quantification of
animal behavior at a resolution not previously imaginable. This has opened up a new field of …
animal behavior at a resolution not previously imaginable. This has opened up a new field of …
The bacterial actin MreB rotates, and rotation depends on cell-wall assembly
…, NS Wingreen, JW Shaevitz… - Proceedings of the …, 2011 - National Acad Sciences
Bacterial cells possess multiple cytoskeletal proteins involved in a wide range of cellular
processes. These cytoskeletal proteins are dynamic, but the driving forces and cellular functions …
processes. These cytoskeletal proteins are dynamic, but the driving forces and cellular functions …
Direct observation of base-pair stepping by RNA polymerase
During transcription, RNA polymerase (RNAP) moves processively along a DNA template,
creating a complementary RNA. Here we present the development of an ultra-stable optical …
creating a complementary RNA. Here we present the development of an ultra-stable optical …
[HTML][HTML] SLEAP: A deep learning system for multi-animal pose tracking
The desire to understand how the brain generates and patterns behavior has driven rapid
methodological innovation in tools to quantify natural animal behavior. While advances in …
methodological innovation in tools to quantify natural animal behavior. While advances in …
Fast animal pose estimation using deep neural networks
The need for automated and efficient systems for tracking full animal pose has increased with
the complexity of behavioral data and analyses. Here we introduce LEAP (LEAP estimates …
the complexity of behavioral data and analyses. Here we introduce LEAP (LEAP estimates …
Backtracking by single RNA polymerase molecules observed at near-base-pair resolution
Escherichia coli RNA polymerase (RNAP) synthesizes RNA with remarkable fidelity in vivo
1 . Its low error rate may be achieved by means of a ‘proofreading’ mechanism comprised of …
1 . Its low error rate may be achieved by means of a ‘proofreading’ mechanism comprised of …
Capillary forces generated by biomolecular condensates
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
mechanisms in living cells for the formation of membraneless compartments or biomolecular …
Whole-brain calcium imaging with cellular resolution in freely behaving Caenorhabditis elegans
…, M Liu, SU Setru, JW Shaevitz… - Proceedings of the …, 2016 - National Acad Sciences
The ability to acquire large-scale recordings of neuronal activity in awake and unrestrained
animals is needed to provide new insights into how populations of neurons generate animal …
animals is needed to provide new insights into how populations of neurons generate animal …
[HTML][HTML] An automated two-dimensional optical force clamp for single molecule studies
We constructed a next-generation optical trapping instrument to study the motility of single
motor proteins, such as kinesin moving along a microtubule. The instrument can be operated …
motor proteins, such as kinesin moving along a microtubule. The instrument can be operated …