[HTML][HTML] Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
…, JS Ravan, AC Rizos, JFK Sauld, JD Sliz… - Communications …, 2022 - nature.com
Background Conventional preclinical models often miss drug toxicities, meaning the harm
these drugs pose to humans is only realized in clinical trials or when they make it to market. …
these drugs pose to humans is only realized in clinical trials or when they make it to market. …
Clear castable polyurethane elastomer for fabrication of microfluidic devices
…, DC Leslie, J McKinney, JP Fraser, JD Sliz… - Lab on a Chip, 2013 - pubs.rsc.org
Polydimethylsiloxane (PDMS) has numerous desirable properties for fabricating microfluidic
devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting…
devices, including optical transparency, flexibility, biocompatibility, and fabrication by casting…
SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion
K Domansky, JD Sliz, N Wen, C Hinojosa… - Microfluidics and …, 2017 - Springer
The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ
Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, …
Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, …
Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications
…, ME Quinn, JS Ravan, AC Rizos, JFK Sauld, JD Sliz… - Biorxiv, 2021 - biorxiv.org
Human organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical
drug discovery and improve success in drug development by recapitulating organ-level …
drug discovery and improve success in drug development by recapitulating organ-level …
Assays to measure nuclear mechanics in interphase cells
P Isermann, PM Davidson, JD Sliz… - Current protocols in …, 2012 - Wiley Online Library
The nucleus is the characteristic hallmark of all eukaryotic cells. The physical properties of
the nucleus reflect important biological characteristics, such as chromatin organization or …
the nucleus reflect important biological characteristics, such as chromatin organization or …
Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
…, JS Ravan, AC Rizos, JFK Sauld, JD Sliz… - Communications …, 2023 - nature.com
There was a mistake in Table 5 of this article. The specificity (%) value in the final row of
Table 5 (the ‘Spheroid’row) read ‘100’, but should have read ‘67’. There was also a …
Table 5 (the ‘Spheroid’row) read ‘100’, but should have read ‘67’. There was also a …
Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments
PM Davidson, J Sliz, P Isermann, C Denais… - Integrative …, 2015 - academic.oup.com
The ability of cells to migrate through tissues and interstitial spaces is an essential factor
during development and tissue homeostasis, immune cell mobility, and in various human …
during development and tissue homeostasis, immune cell mobility, and in various human …
Reproducing human and cross-species drug toxicities using a Liver-Chip
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate
drugs may produce discordant results or fail to predict complications in humans, contributing …
drugs may produce discordant results or fail to predict complications in humans, contributing …
Robotic fluidic coupling and interrogation of multiple vascularized organ chips
…, B O'Connor, TE Park, H Sanchez, J Sliz… - Nature biomedical …, 2020 - nature.com
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we …
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we …
Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model
Induction of intestinal drug metabolizing enzymes can complicate the development of new
drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in …
drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in …