User profiles for Jouke-Jan Hottenga

Jouke- Jan Hottenga

Senior Researcher, Vrije Universiteit Amsterdam
Verified email at vu.nl
Cited by 89229

Genome-wide association study identifies 74 loci associated with educational attainment

…, EG Holliday, G Homuth, MA Horan, JJ Hottenga… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

…, TB Harris, JM Harris, EG Holliday, JJ Hottenga… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

…, A Hofman, R Holle, EG Holliday, JJ Hottenga… - science, 2013 - science.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Variants in MTNR1B influence fasting glucose levels

…, SC Potter, MR Erdos, S Sanna, JJ Hottenga… - Nature …, 2009 - nature.com
To identify previously unknown genetic loci associated with fasting glucose concentrations,
we examined the leading association signals in ten genome-wide association scans …

The power of genetic diversity in genome-wide association studies of lipids

…, K Yoon, C Medina-Gomez, A Pitsillides, JJ Hottenga… - Nature, 2021 - nature.com
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

[HTML][HTML] The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

…, M Hoogman, LE Hong, N Hosten, JJ Hottenga… - Brain imaging and …, 2014 - Springer
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a
collaborative network of researchers working together on a range of large-scale studies that …

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

…, C Hodgkinson, P Hoffmann, J Jan Hottenga… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

Genetic studies of body mass index yield new insights for obesity biology

…, Q Helmer, C Hengstenberg, O Holmen, JJ Hottenga… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Biological, clinical and population relevance of 95 loci for blood lipids

…, E Ingelsson, W Igl, G Kees Hovingh, JJ Hottenga… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

…, NL Heard-Costa, V Hoesel, JJ Hottenga… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …