Background Type 2 diabetes mellitus is increasingly common, primarily because of increases
in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be …

Background Lifestyle interventions can prevent the deterioration of impaired glucose tolerance
to manifest type 2 diabetes, at least as long as the intervention continues. In the extended …

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 individuals …

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …

Background The cardiovascular risk factor levels of the population have been assessed in
Finland since 1972. In the beginning the surveys were done to evaluate the North Karelia …

Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the
importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc …

Background In the late 1960s, coronary heart disease (CHD) mortality among Finnish men
was the highest in the world. From 1972 to 2007, risk factor surveys have been carried out to …

Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is
strongly associated with cardiovascular disease. We sought to identify genetic variants that …

OBJECTIVE Diabetes is accompanied with a chronic low-grade inflammation, which may in
part be mediated by endotoxins derived from Gram-negative bacteria. RESEARCH DESIGN …

Background: Coffee consumption is associated with a decreased risk of type 2 diabetes.
Suggested mechanisms underlying the association have included attenuation of subclinical …