Multifunctional nanoparticles for multimodal imaging and theragnosis

DE Lee, H Koo, IC Sun, JH Ryu, K Kim… - Chemical Society …, 2012 - pubs.rsc.org
Nanomedicine is the biomedical application of nanoscale materials for diagnosis and therapy
of disease. Recent advances in nanotechnology and biotechnology have contributed to …

Tumor-targeting multi-functional nanoparticles for theragnosis: new paradigm for cancer therapy

JH Ryu, H Koo, IC Sun, SH Yuk, K Choi, K Kim… - Advanced drug delivery …, 2012 - Elsevier
Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one
integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the …

[HTML][HTML] Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

…, MMC Bastings, B Nathwani, JH Ryu… - Nature …, 2017 - nature.com
DNA nanostructures have evoked great interest as potential therapeutics and diagnostics
due to ease and robustness of programming their shapes, site-specific functionalizations and …

[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment

J Park, Y Choi, H Chang, W Um, JH Ryu, IC Kwon - Theranostics, 2019 - ncbi.nlm.nih.gov
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

T‐cell‐mimicking nanoparticles for cancer immunotherapy

…, JR Lee, S Kang, J Han, JH Koo, JH Ryu… - Advanced …, 2020 - Wiley Online Library
Cancer immunotherapies, including adoptive T cell transfer and immune checkpoint
blockades, have recently shown considerable success in cancer treatment. Nevertheless, …

Nanoprobes for biomedical imaging in living systems

H Koo, MS Huh, JH Ryu, DE Lee, IC Sun, K Choi… - Nano Today, 2011 - Elsevier
Recent progress in bio and nanotechnology enables the development of various nanoprobes
for biomedical imaging. The detection and imaging of specific changes in biological …

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

…, TJ Kim, L Kang, YJ Kim, MK Kang, J Kim, JH Ryu… - Biomaterials, 2020 - Elsevier
Exosomes and extracellular nanovesicles (NV) derived from mesenchymal stem cells (MSC)
may be used for the treatment of ischemic stroke owing to their multifaceted therapeutic …

Cancer-activated doxorubicin prodrug nanoparticles induce preferential immune response with minimal doxorubicin-related toxicity

…, J Kim, Y Moon, HY Kim, J Park, Y Park, IS Kim, JH Ryu… - Biomaterials, 2021 - Elsevier
The effective chemotherapeutic drug, doxorubicin (DOX), elicits immunogenic cell death (ICD)
and additional anticancer immune responses during chemotherapy. However, it also …

Tumor‐targeting glycol chitosan nanoparticles for cancer heterogeneity

JH Ryu, HY Yoon, IC Sun, IC Kwon… - Advanced Materials, 2020 - Wiley Online Library
Nanomedicine is extensively employed for cancer treatment owing to its unique advantages
over conventional drugs and imaging agents. This increased attention to nanomedicine, …

[HTML][HTML] Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy

S Lim, J Park, MK Shim, W Um, HY Yoon, JH Ryu… - Theranostics, 2019 - ncbi.nlm.nih.gov
Cancer immunotherapy is an attractive treatment option under clinical settings. However,
the major challenges of immunotherapy include limited patient response, limited tumor …