Depleting regulatory T cells (T reg cells) to counteract immunosuppressive features of the
tumor microenvironment (TME) is an attractive strategy for cancer treatment; however, …

The risk of cancer and associated mortality increases substantially in humans from the age
of 65 years onwards 1 , 2 , 3 , 4 , 5 – 6 . Nonetheless, our understanding of the complex …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic growth…

In this work the different concentrations of soluble elements in soils from natural (peridotitic
soils) and anthropogenic (soils affected by a pyrite-mine spill) origin, are used to determine …

Most tumours have an aberrantly activated lipid metabolism 1 , 2 that enables them to
synthesize, elongate and desaturate fatty acids to support proliferation. However, only particular …

The inclusive breakup for the Li 11+ Pb 208 reaction at energies around the Coulomb barrier
has been measured for the first time. A sizable yield of Li 9 following the Li 11 dissociation …

Cancer metastasis requires the transient activation of cellular programs enabling dissemination
and seeding in distant organs 1 . Genetic, transcriptional and translational heterogeneity …

Metabolism is at the cornerstone of all cellular functions and mounting evidence of its
deregulation in different diseases emphasizes the importance of a comprehensive understanding …

Four silicas, two fumed (one hydrophilic and one hydrophobic) and two precipitated silicas (one
hydrophilic and one hydrophobic), were added to a thermoplastic polyurethane (PU). …

Proton halo effects in the 8 B+ 64 Zn reaction at an energy around 1.5 times the Coulomb
barrier have been studied at HIE-ISOLDE CERN using, for the first time, the only existing …