Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin

R Herzog, JM Sacnun, G González-Mateo… - Science Translational …, 2021 - science.org
Life-saving renal replacement therapy by peritoneal dialysis (PD) is limited in use and
duration by progressive impairment of peritoneal membrane integrity and homeostasis. …

[HTML][HTML] Peritoneal dialysis fluid supplementation with alanyl-glutamine attenuates conventional dialysis fluid-mediated endothelial cell injury by restoring perturbed …

…, A Wagner, M Unterwurzacher, JM Sacnun… - Biomolecules, 2020 - mdpi.com
Long-term clinical outcome of peritoneal dialysis (PD) depends on adequate removal of small
solutes and water. The peritoneal endothelium represents the key barrier and peritoneal …

[HTML][HTML] Proteome-wide differential effects of peritoneal dialysis fluid properties in an in vitro human endothelial cell model

JM Sacnun, R Hoogenboom, F Eibensteiner… - International Journal of …, 2022 - mdpi.com
To replace kidney function, peritoneal dialysis (PD) utilizes hyperosmotic PD fluids with
specific physico-chemical properties. Their composition induces progressive damage of the …

[HTML][HTML] Understanding cell model characteristics—RNA expression profiling in primary and immortalized human mesothelial cells, and in human vein and …

I Marinovic, M Bartosova, R Herzog, JM Sacnun… - Cells, 2022 - mdpi.com
In vitro studies are essential in pre-clinical research. While choice of cell lines is often driven
by handling and cost-effectiveness, in-depth knowledge on specific characteristics is scant. …

Proteomic study of mesothelial and endothelial cross-talk: key lessons

JM Sacnun, R Herzog, K Kratochwill - Expert Review of Proteomics, 2022 - Taylor & Francis
Introduction The peritoneum, pleura, and pericardium are yet understudied multicellular
systems where mesothelial cells (MCs) and endothelial cells (ECs) are in close proximity. …

Dual function of HYPONASTIC LEAVES 1 during early skotomorphogenic growth in Arabidopsis

JM Sacnun, R Crespo, J Palatnik, R Rasia… - The Plant …, 2020 - Wiley Online Library
Seeds germinating underground display a specific developmental programme, termed
skotomorphogenesis, to ensure survival of the emerging seedlings until they reach the light. They …

[HTML][HTML] In-depth analysis of the extracorporeal proteome adsorbed to dialysis membranes during hemodialysis

L Daniel-Fischer, IJ Sobieszek, A Wagner, JM Sacnun… - Membranes, 2022 - mdpi.com
Used hemodialysis membranes (HD-M) are a valuable reservoir of biological information.
Proteins bind to HD-M, but whether this process depends on the type of membrane or patient …

[HTML][HTML] A Meta-Analysis of Human Transcriptomics Data in the Context of Peritoneal Dialysis Identifies Novel Receptor-Ligand Interactions as Potential Therapeutic …

M Evgeniou, JM Sacnun, K Kratochwill… - International Journal of …, 2021 - mdpi.com
Peritoneal dialysis (PD) is one therapeutic option for patients with end-stage kidney disease
(ESKD). Molecular profiling of samples from PD patients using different Omics technologies …

Effect of cellular senescence on the response of human peritoneal mesothelial cells to TGF-β

…, A Malińska, M Unterwurzacher, JM Sacnun… - 2024 - researchsquare.com
Transforming growth factor β (TGF-β) is implicated in both mesothelial-to-mesenchymal
transition (MMT) and cellular senescence of human peritoneal mesothelial cells (HPMCs). We …

MO711: Evaluation of an in Vitro Co-Culture Model for Studying Modulation of Cross-Talk between Endothelial and Mesothelial Cells by Cytoprotective Additives in …

J Manuel Sacnun, R Herzog… - Nephrology Dialysis …, 2022 - academic.oup.com
BACKGROUND AND AIMS Peritoneal dialysis (PD) is a life-saving renal replacement
therapy. The composition of all currently available peritoneal dialysis fluids (PDF) triggers …