A fundamental challenge in the post-genome era is to understand and annotate the consequences
of genetic variation, particularly within the context of human tissues. We present a set …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

The distinction between the neurodegenerative changes that accompany normal ageing
and those that characterise Alzheimer's disease is not clear. The resolution of this issue has …

We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid
β-peptide (Aβ) and degeneration of neurons in brain regions such as the hippocampus, …

Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

A hexanucleotide repeat expansion (HRE), (GGGGCC) n , in C9orf72 is the most common
genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and …

Endocytosis is critical to the function and fate of molecules important to Alzheimer’s disease
(AD) etiology, including the β protein precursor (βPP), amyloid β (Aβ) peptide, and …

Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important
in the survival of dopamine neurons in Parkinson's disease (PD). We show that parkin is S-…