Physiological levels of shear stress alter the genetic programm of cultured endothelial cells
and are associated with reduced cellular turnover rates and formation of atherosclerotic …

The nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylase Sir2
regulates life-span in various species. Mammalian homologs of Sir2 are called sirtuins (SIRT1–…

Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization of
ischemic tissue. Ex vivo expansion of EPCs might be useful for potential clinical cell therapy …

Fluid shear stress alters the morphology and function of the endothelium by activating several
kinases. Furthermore, shear stress potently inhibits apoptosis of endothelial cells. Since …

Background— The underlying molecular mechanisms of the vasculoprotective effects of
physical exercise are incompletely understood. Telomere erosion is a central component of …

Angiotensin II (Ang II) importantly contributes to the pathobiology of atherosclerosis. Since
endothelial injury is a key event early in the pathogenesis of atherosclerosis, we tested the …

In cultured human endothelial cells, physiological levels of NO prevent apoptosis and
interfere with the activation of the caspase cascade. In vitro data have demonstrated that NO …

Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis,
hypertension, and restenosis, in part by promoting vascular smooth muscle cell (VSMC) growth. …

Thioredoxin 1 (Trx) is a known redox regulator that is implicated in the redox control of cell
growth and apoptosis inhibition. Here we show that Trx is essential for maintaining the content …

Aging is associated with a rise in intracellular reactive oxygen species (ROS) and a loss of
telomerase reverse transcriptase activity. Incubation with H 2 O 2 induced the nuclear export …