Characterization of a functional NF-κB site in the human interleukin 1β promoter: evidence for a positive autoregulatory loop

…, A Roulston, IVY Kwan, N Pepin, J Lacoste… - … and cellular biology, 1993 - Taylor & Francis
The -300 region of the interleukin 1β (IL-1β) promoter contains a functional NF-κB binding
site composed of the decamer sequence 5'-GGGAAAATCC-3'. Probes representing the -300 …

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

A Kumar, J Haque, J Lacoste… - Proceedings of the …, 1994 - National Acad Sciences
The induction of interferon (IFN) genes by viruses or double-stranded RNA (dsRNA) requires
the assembly of a complex set of transcription factors on responsive DNA elements of IFN …

Live-cell microscopy–tips and tools

MM Frigault, J Lacoste, JL Swift… - Journal of cell …, 2009 - journals.biologists.com
Imaging of living cells and tissue is now common in many fields of the life and physical
sciences, and is instrumental in revealing a great deal about cellular dynamics and function. It is …

Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKε molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

R Lin, J Lacoste, P Nakhaei, Q Sun, L Yang… - Journal of …, 2006 - Am Soc Microbiol
Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-I that plays
an essential role in signaling to the host antiviral response. Recently, the adapter molecule …

RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I

M Solis, P Nakhaei, M Jalalirad, J Lacoste… - Journal of …, 2011 - Am Soc Microbiol
The rapid induction of type I interferon (IFN) is essential for establishing innate antiviral
responses. During infection, cytoplasmic viral RNA is sensed by two DExD/H box RNA helicases, …

QUAREP‐LiMi: A community‐driven initiative to establish guidelines for quality assessment and reproducibility for instruments and images in light microscopy

…, N Kobayashi, G Krens, S Kunis, J Lacoste… - Journal of …, 2021 - Wiley Online Library
A modern day light microscope has evolved from a tool devoted to making primarily empirical
observations to what is now a sophisticated , quantitative device that is an integral part of …

Towards community-driven metadata standards for light microscopy: tiered specifications extending the OME model

…, CM Brown, AD Corbett, O Faklaris, J Lacoste… - Nature …, 2021 - nature.com
Rigorous record-keeping and quality control are required to ensure the quality, reproducibility
and value of imaging data. The 4DN Initiative and BINA here propose light Microscopy …

Ubiquitin-regulated recruitment of IκB kinase ε to the MAVS interferon signaling adapter

…, M Vilasco, M Arguello, Q Sun, J Lacoste… - … and cellular biology, 2009 - Taylor & Francis
Induction of the antiviral interferon response is initiated upon recognition of viral RNA
structures by the RIG-I or Mda-5 DEX(D/H) helicases. A complex signaling cascade then …

Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase

K Nolan, J Lacoste, JT Parsons - Molecular and cellular biology, 1999 - Am Soc Microbiol
Focal adhesion kinase (FAK) has been implicated in cellular processes that control cell
adhesion, migration, cell cycle progression, and apoptosis. FRNK (FAK-related nonkinase) is the …

[HTML][HTML] Micro-Meta App: an interactive tool for collecting microscopy metadata based on community specifications

…, MS Itano, DP Keeley, S Kunis, J Lacoste… - Nature …, 2021 - nature.com
For quality, interpretation, reproducibility and sharing value, microscopy images should be
accompanied by detailed descriptions of the conditions that were used to produce them. Micro…