Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
An aged circulatory environment can activate microglia, reduce neural precursor cell activity
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …
and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate …
[HTML][HTML] S100A8/A9 is a marker for the release of neutrophil extracellular traps and induces neutrophil activation
EGG Sprenkeler, J Zandstra, ND van Kleef… - Cells, 2022 - mdpi.com
Neutrophils are the most abundant innate immune cells in the circulation and they are the
first cells recruited to sites of infection or inflammation. Almost half of the intracellular protein …
first cells recruited to sites of infection or inflammation. Almost half of the intracellular protein …
[PDF][PDF] Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular …
…, AE van Beek, E Willems, J Zandstra… - The American Journal of …, 2021 - cell.com
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…
[HTML][HTML] A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children …
HR Jackson, J Zandstra, S Menikou… - The Lancet Digital …, 2023 - thelancet.com
Background Differentiating between self-resolving viral infections and bacterial infections in
children who are febrile is a common challenge, causing difficulties in identifying which …
children who are febrile is a common challenge, causing difficulties in identifying which …
[HTML][HTML] Biomarkers for the discrimination of acute Kawasaki disease from infections in childhood
J Zandstra, A Van de Geer, MWT Tanck… - Frontiers in …, 2020 - frontiersin.org
Background: Kawasaki disease (KD) is a vasculitis of early childhood mimicking several
infectious diseases. Differentiation between KD and infectious diseases is essential as KD's …
infectious diseases. Differentiation between KD and infectious diseases is essential as KD's …
[HTML][HTML] Future biomarkers for infection and inflammation in febrile children
J Zandstra, I Jongerius, TW Kuijpers - Frontiers in immunology, 2021 - frontiersin.org
Febrile patients, suffering from an infection, inflammatory disease or autoimmunity may
present with similar or overlapping clinical symptoms, which makes early diagnosis difficult. …
present with similar or overlapping clinical symptoms, which makes early diagnosis difficult. …
Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier
An aged circulatory environment can promote brain dysfunction and we hypothesized that
the blood-brain barrier (BBB) mediates at least some of these effects. We observe brain …
the blood-brain barrier (BBB) mediates at least some of these effects. We observe brain …
Biomarkers to predict infection and infection-related complications during chemotherapy-induced neutropenia in acute myeloid leukaemia: a pilot study
A van de Geer, J Zandstra… - British journal of …, 2021 - pubmed.ncbi.nlm.nih.gov
… 1 , Judith Zandstra …
Biomarkers for the Discrimination of Acute Kawasaki Disease From Infections in Childhood
…, HR Yu, S Hasegawa, J Zandstra, J Zandstra… - Kawasaki …, 2021 - books.google.com
Background: Kawasaki disease (KD) is a vasculitis of early childhood mimicking several
infectious diseases. Differentiation between KD and infectious diseases is essential as KD’s …
infectious diseases. Differentiation between KD and infectious diseases is essential as KD’s …
Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR levels and age-related macular degeneration
…, A van Beek, E Willems, J Zandstra… - Am J Hum …, 2021 - research.manchester.ac.uk
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…