User profiles for Jui-Hua Hsieh
 | Jui-Hua HsiehNational Toxicology Program, National Institute of Environmental Health Sciences Verified email at nih.gov Cited by 3129 |
The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance
The concordance of RNA-sequencing (RNA-seq) with microarrays for genome-wide analysis
of differential gene expression has not been rigorously assessed using a range of chemical …
of differential gene expression has not been rigorously assessed using a range of chemical …
[HTML][HTML] A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives
…, RB Blain, AJ Shapiro, SD Holmgren, JH Hsieh… - Toxicology, 2019 - Elsevier
Recent studies report widespread usage or exposure to a variety of chemicals with structural
or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. …
or functional similarity to bisphenol A (BPA), referred to as BPA analogues or derivatives. …
Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity
Due to their toxicity and persistence in the environment, brominated flame retardants (BFRs)
are being phased out of commercial use, leading to the increased use of alternative …
are being phased out of commercial use, leading to the increased use of alternative …
[HTML][HTML] In silico toxicology protocols
…, JS Harvey, J Hillegass, M Honma, JH Hsieh… - Regulatory Toxicology …, 2018 - Elsevier
The present publication surveys several applications of in silico (ie, computational) toxicology
approaches across different industries and institutions. It highlights the need to develop …
approaches across different industries and institutions. It highlights the need to develop …
[HTML][HTML] Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
The US Tox21 program has screened a library of approximately 10,000 (10K) environmental
chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist …
chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist …
An intuitive approach for predicting potential human health risk with the Tox21 10k library
In vitro–in vivo extrapolation (IVIVE) analyses translating high-throughput screening (HTS)
data to human relevance have been limited. This study represents the first report applying …
data to human relevance have been limited. This study represents the first report applying …
Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity
KR Ryan, O Sirenko, F Parham, JH Hsieh, EF Cromwell… - Neurotoxicology, 2016 - Elsevier
Due to the increasing prevalence of neurological disorders and the large number of untested
compounds in the environment, there is a need to develop reliable and efficient screening …
compounds in the environment, there is a need to develop reliable and efficient screening …
Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward …
A Alzualde, M Behl, NS Sipes, JH Hsieh, A Alday… - Neurotoxicology and …, 2018 - Elsevier
Following the voluntary phase-out of brominated flame retardants (BFRs) due to their
environmental persistence and toxicity, the organophosphorus flame retardants (OPFRs) are …
environmental persistence and toxicity, the organophosphorus flame retardants (OPFRs) are …
[HTML][HTML] Genetic toxicology in silico protocol
…, JS Harvey, J Hillegass, M Honma, JH Hsieh… - Regulatory Toxicology …, 2019 - Elsevier
In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such
methods is increasing in all applications but especially for regulatory submissions, such as …
methods is increasing in all applications but especially for regulatory submissions, such as …
[HTML][HTML] A high-throughput approach to identify specific neurotoxicants/developmental toxicants in human neuronal cell function assays
…, S Gutbier, S Klima, L Hoelting, K Pinto-Gil, JH Hsieh… - Altex, 2018 - ncbi.nlm.nih.gov
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing
a test battery covering most of the relevant adverse outcome pathways may close this gap …
a test battery covering most of the relevant adverse outcome pathways may close this gap …