INTRODUCTION More than 50% of patients treated with chimeric antigen receptor (CAR)–T
cells for B cell malignancies develop progressive disease after CAR therapy, and these …

T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …

For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant
metastatic disease and, therefore, an important prognostic factor. Beyond its utility as a …

Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from
back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins, …

Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms
in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. …

SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive
identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified …

Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell (Tex)
state with reduced effector function. However, whether all antigen-specific T cell clones …

T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells (HSCs),
leading to clonal haematopoiesis 1 . These lesions are precursors for blood cancers …