Combined PARP and immune checkpoint inhibition has yielded encouraging results in
ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we show that …

We engineered a panel of murine fallopian tube epithelial cells bearing mutations typical of
HGSC and capable of forming tumors in syngeneic immunocompetent hosts. These models …

This study uncovers that ATX–LPA is a central immunosuppressive pathway in the ovarian
tumor microenvironment. Ablating this axis sensitizes ovarian cancer hosts to various …

The majority of high-grade serous ovarian cancers (HGSCs) are deficient in homologous
recombination (HR) DNA repair, most commonly due to mutations or hypermethylation of the …

Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic
instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic …

Anduril is an analysis and integration framework that facilitates the design, use, parallelization
and reproducibility of bioinformatics workflows. Anduril has been upgraded to use Scala …

Although shunt overdrainage is a well-known complication in hydrocephalus management,
the problem has been underestimated. Current literature suggests that the topic requires …

The kinetics of the nitrosation of morpholine and diethylamine in the presence of formaldehyde
has been studied at pH values between 6.5–8.2 and 6.9–8.7, respectively. The results …

Motivation Single-cell proteomics technologies, such as mass cytometry, have enabled
characterization of cell-to-cell variation and cell populations at a single-cell resolution. These …