Despite recent major advances including reprogramming and directed cardiac differentiation
of human cells, therapeutic application of in vitro engineered myocardial tissue is still not …

Aims We explored the use of highly purified murine and human pluripotent stem cell (PSC)-derived
cardiomyocytes (CMs) to generate functional bioartificial cardiac tissue (BCT) and …

In most pluripotent stem cell differentiation protocols the formation of embryoid bodies (EBs)
is an important step. Here we describe a rapid, straightforward soft lithography approach for …

Stem cell-based cardiac tissue engineering is a promising approach for regenerative therapy
of the injured heart. At present, the small number of stem cell-derived cardiomyocytes that …

Hydrogels are three-dimensional water-insoluble hydrophilic natural or synthetic polymer
networks made up of crosslinked water-soluble polymers. The purpose of this study was to …

In addition to antioxidative and anti-inflammatory properties, activators of the cytoprotective
nuclear factor erythroid-2-like-2 (NRF2) signaling pathway have antiviral effects, but the …

Background Human pluripotent stem cells (PSCs) open new windows for basic research
and regenerative medicine due to their remarkable properties, ie their ability to self-renew …

Noonan syndrome (NS), the most common among RASopathies, is caused by germline
variants in genes encoding components of the RAS-MAPK pathway. Distinct variants, including …

Myocardial interstitial fibrosis (MIF) is characterized by excessive extracellular matrix (ECM)
deposition, increased myocardial stiffness, functional weakening, and compensatory …

The endodermal germ layer gives rise to respiratory epithelium, hepatocytes, pancreatic cells
and intestinal lineages, among other cell types. These lineages can be differentiated from …