In the current COVID-19 pandemic context, proposing and validating effective treatments
represents a major challenge. However, the scarcity of biologically relevant pre-clinical models …

In response to the current pandemic caused by the novel SARS-CoV-2, identifying and
validating effective therapeutic strategies is more than ever necessary. We evaluated the in vitro …

During their nuclear replication stage, influenza viruses hijack the host splicing machinery
to process some of their RNA segments, the M and NS segments. In this review, we provide …

Acute respiratory infections, a large part being of viral origin, constitute a major public health
issue. To propose alternative and/or new therapeutic approaches, it is necessary to …

Influenza viruses replicate their single-stranded RNA genomes in the nucleus of infected
cells and these replicated genomes (vRNPs) are then exported from the nucleus to the …

Influenza A viruses (IAV) are known to modulate and “hijack” several cellular host mechanisms,
including gene splicing and RNA maturation machineries. These modulations alter host …

The interplay between influenza A viruses (IAV) and the p53 pathway has been reported in
several studies, highlighting the antiviral contribution of p53. Here, we investigated the …

NOD-like receptor protein 3 (NLRP3) inflammasome activation triggers caspase-1 activation-induced
maturation of interleukin (IL)-1β and IL-18 and therefore is important for the …

The interplay between influenza A viruses (IAV) and p53 has only been reported in a limited
number of studies, mainly focusing on the antiviral role of p53. We investigated the impact of …

Human metapneumovirus (HMPV) is a major pediatric respiratory pathogen with currently
no specific treatment or licensed vaccine. Different strategies to prevent this infection have …