The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated,
as inadequate bone formation results in low bone mass and skeletal fragility, and over-…

As the only cells definitively shown to degrade bone, osteoclasts are key mediators of
skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and …

Osteoclasts are specialized secretory cells of the myeloid lineage important for normal
skeletal homeostasis as well as pathologic conditions of bone including osteoporosis, …

Appreciation of the role of the gut microbiome in regulating vertebrate metabolism has
exploded recently. However, the effects of gut microbiota on skeletal growth and homeostasis …

Background: Exit from mitosis requires inactivation of mitotic cyclin-dependent kinases (CDKs).
A key mechanism of CDK inactivation is ubiquitin-mediated cyclin proteolysis, which is …

Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinase–cyclin complexes,
primarily by ubiquitin-dependent cyclin proteolysis. Cyclin destruction is regulated by a …

Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close
proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to …

Background: Following chromosome segregation in anaphase, ubiquitin-dependent
degradation of mitotic cyclins contributes to the exit from mitosis. A key step in this process is …

Increased osteoclastic bone resorption leads to periarticular erosions and systemic osteoporosis
in RA patients. Although a great deal is known about how osteoclasts differentiate from …

The immune system and bone are intimately linked with significant physical and functionally
related interactions. The innate immune system functions as an immediate response system …