The tauopathy-like phenotype observed in the rTg4510 mouse line, in which human tau
P301L expression specifically within the forebrain can be temporally controlled, has largely …

The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has
been firmly established, but the mechanisms through which it exerts its pathogenic effects …

Background The genetic underpinnings of late-onset Alzheimer’s disease (LOAD) are yet to
be fully elucidated. Although numerous LOAD-associated loci have been discovered, the …

Background In the post-GWAS era, there is an unmet need to decode the underpinning
genetic etiologies of late-onset Alzheimer’s disease (LOAD) and translate the associations to …

Tau is a microtubule-associated protein that becomes dysregulated in a group of neurodegenerative
diseases called tauopathies. Differential tau isoforms, expression levels, promoters, …

Background Decoding the genetic mechanisms of late-onset Alzheimer’s disease (LOAD) is
a major challenge in the post-GWAS era, since the majority of the LOAD associated SNPs …

Background The genetic underpinnings of late‐onset Alzheimer’s disease (LOAD) are yet to
be fully elucidated. Although numerous LOAD‐associated loci have been discovered, the …

Background The genetic architecture of late‐onset Alzheimer’s disease (LOAD) is yet to be
fully explored. While GWAS discovered numerous LOAD‐associated loci, the causal variants …

Tau is the main axonal microtubule-associated protein in the mammalian central nervous
system (CNS) and functions primarily in microtubule assembly and axonal transport. However, …

Background In the post‐GWAS era for late‐onset Alzheimer’s disease (LOAD), the precise
disease‐causing genes, the specific causal variants, and molecular mechanisms mediating …