Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19
…, J Schneider, J Kager, M Frolova, J Horstmann… - Gut …, 2022 - Taylor & Francis
There is a growing debate about the involvement of the gut microbiome in COVID-19, although
it is not conclusively understood whether the microbiome has an impact on COVID-19, or …
it is not conclusively understood whether the microbiome has an impact on COVID-19, or …
[HTML][HTML] Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion
JA Horstmann, M Lunelli, H Cazzola… - Nature …, 2020 - nature.com
The long external filament of bacterial flagella is composed of several thousand copies of a
single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in …
single protein, flagellin. Here, we explore the role played by lysine methylation of flagellin in …
[HTML][HTML] Mucosal-associated invariant T (MAIT) cells are highly activated and functionally impaired in COVID-19 patients
…, JR Wiessner, F Voit, J Schneider, J Horstmann… - Viruses, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as …
syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as …
Flagellin phase‐dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation
JA Horstmann, E Zschieschang, T Truschel… - Cellular …, 2017 - Wiley Online Library
The flagellum is a sophisticated nanomachine and an important virulence factor of many
pathogenic bacteria. Flagellar motility enables directed movements towards host cells in a …
pathogenic bacteria. Flagellar motility enables directed movements towards host cells in a …
Complicated grief in patients with unipolar depression
A Kersting, K Kroker, J Horstmann, P Ohrmann… - Journal of affective …, 2009 - Elsevier
BACKGROUND: The loss of a close family member (eg child or spouse) has been shown to
be one of the most stressful life-events increasing the risk of affective disorders. In the …
be one of the most stressful life-events increasing the risk of affective disorders. In the …
Molecular organization of soluble type III secretion system sorting platform complexes
…, J Heidemann, D Svergun, JA Horstmann… - Journal of molecular …, 2019 - Elsevier
Many medically relevant Gram‐negative bacteria use the type III secretion system (T3SS) to
translocate effector proteins into the host for their invasion and intracellular survival. A multi-…
translocate effector proteins into the host for their invasion and intracellular survival. A multi-…
Association of MAO-A variant with complicated grief in major depression
A Kersting, K Kroker, J Horstmann, BT Baune… - …, 2008 - karger.com
Background/Aims: It has been suggested that monoamine oxidase A (MAO-A) activity is
involved in the pathogenesis of major depression. Bereavement-related complicated grief …
involved in the pathogenesis of major depression. Bereavement-related complicated grief …
[HTML][HTML] SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner
DO Saleh, JA Horstmann, M Giralt-Zúñiga… - PLoS …, 2023 - journals.plos.org
Both the bacterial flagellum and the evolutionary related injectisome encoded on the Salmonella
pathogenicity island 1 (SPI-1) play crucial roles during the infection cycle of Salmonella …
pathogenicity island 1 (SPI-1) play crucial roles during the infection cycle of Salmonella …
Enhancing pre-clinical research with simplified intestinal cell line models
…, K Nehlsen, S Damigos, J Horstmann… - Journal of Tissue …, 2024 - journals.sagepub.com
Two-dimensional culture remains widely employed to determine the bioavailability of orally
delivered drugs. To gain more knowledge about drug uptake mechanisms and risk …
delivered drugs. To gain more knowledge about drug uptake mechanisms and risk …
Epidemiologic Risk Factors in a Comparison of a Barrett Esophagus Registry (BarrettNET) and a Case–Control Population in Germany
…, J Slotta-Huspenina, KF Becker, J Horstmann… - Cancer prevention …, 2020 - AACR
Endoscopic screening for Barrett's esophagus as the major precursor lesion for esophageal
adenocarcinoma is mostly offered to patients with symptoms of gastroesophageal reflux …
adenocarcinoma is mostly offered to patients with symptoms of gastroesophageal reflux …