In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and
other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across …

DNA base modifications diversify the genome and are essential players in development. Yet,
their influence on DNA physical properties and the ensuing effects on genome metabolism …

RNA polymerase (Pol) I transcribes the ribosomal RNA precursor in all eukaryotes. The
mechanisms ‘activation by cleft contraction’ and ‘hibernation by dimerization’ are unique to the …

… Author links open overlay panel Qianmin Wang a b c 1 , Julia L. Daiß d 1 , Youwei Xu e , …
Human Pol III in elongation state; L. Human Pol III in pre-termination state; M. Yeast Pol III in …

Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major
determinant of cellular growth, and dysregulation is observed in many cancer types. Here, we …

The ribosomal RNA precursor (pre-rRNA) comprises three of the four ribosomal RNAs and
is synthesized by RNA polymerase (Pol) I. Here, we describe the mechanisms of Pol I …

Transcription of the ribosomal RNA precursor by RNA polymerase (Pol) I is a major determinant
of cellular growth and dysregulation is observed in many cancer types. Here, we present …

During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured
precursors into mature miRNAs. These processing steps can be posttranscriptionally …

… , and Julia Norton. Finally, special thanks to our sponsor on this effort, L. Clifford McDonald
at the Centers for Disease Control and Prevention for his continued advice and support. …

… Daiss a i 3 … John L. Daiss, pH.D., works more than half-time for MicroB-plex, Inc. and
also serves as a Research Associate Professor at the University of Rochester Medical Center…