Increased energy requirement and metabolic reprogramming are hallmarks of cancer cells.
We show that metabolic alterations in hematopoietic cells are fundamental to the …

The ubiquitous mitochondrial J-protein Jac1, called HscB in Escherichia coli, and its partner
Hsp70 play a critical role in the transfer of Fe–S clusters from the scaffold protein Isu to …

The tumor suppressor p53 limits tumorigenesis by inducing apoptosis, cell cycle arrest, and
senescence. Although p53 is known to limit inflammation during tumor development, its role …

Background: Little is known regarding the dynamics of the interaction of proteins with the Fe/S
cluster scaffold Isu1. Results: Three conserved Isu1 residues are critical for interaction …

In mitochondria FeS clusters, prosthetic groups critical for the activity of many proteins, are
first assembled on Isu, a 14-kDa scaffold protein, and then transferred to recipient apoproteins…

Interlayer adhesion is one of the most pivotal aspects related to mechanical performance
and durability of 3D printed concrete. However, due to continuous printing of multi-layered …

The accumulation of senescent cells promotes aging, but a molecular mechanism that senescent
cells use to evade immune clearance and accumulate remains to be elucidated. Here, …

Cellular senescence, a highly coordinated and programmed cellular state, has a functional
role in both lung physiology and pathology. While the contribution of senescent cells is …

Cellular senescence, a stable form of cell cycle arrest, accompanied by pronounced secretory
activity, has functional roles in both physiological and pathological conditions. Although …

Cellular senescence is a stable state of cell cycle arrest that regulates tissue integrity and
protects the organism from tumorigenesis. However, the accumulation of senescent cells …