Since the initial description of phage display technology for the generation of human antibodies,
a variety of selection methods has been developed. The most critical parameter for all in …

Triple-negative (TN) breast cancer is an aggressive subtype of breast cancer associated with
a unique set of epidemiologic and genetic risk factors. We conducted a two-stage genome-…

Introduction Obese breast cancer patients have worse prognosis than normal weight
patients, but the level at which obesity is prognostically unfavorable is unclear. Methods This …

Background Prenatal exposure to polychlorinated biphenyls (PCBs) and lead are thought to
be risk factors for attention-deficit hyperactivity disorder (ADHD), whereas the prenatal …

Cohort trials have shown evidence that obesity and a low level of physical activity are not
only associated with a higher risk of developing breast cancer, but also with an increased risk …

White adipose tissue (WAT) fibrosis, characterized by an excess of extracellular (ECM) matrix
components, is strongly associated with WAT inflammation and dysfunction due to obesity. …

The tumor necrosis factor (TNF)-receptor 1–associated death domain protein (TRADD)
mediates induction of apoptosis as well as activation of NF-κB by cellular TNF-receptor 1 (TNFR1)…

The progesterone receptor (PR) has been increasingly well described as an important
mediator of the pathogenesis and progression of breast cancer. The aim of this study was to …

A cascade reaction consisting of a Heck reaction followed by an enzyme-catalyzed reaction
is carried out in different aqueous solutions. In particular, the impact of the structuring of the …

Most individuals with rare diseases initially consult their primary care physician. For a subset
of rare diseases, efficient diagnostic pathways are available. However, ultra-rare diseases …