Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos.
Numerous kinesins and myosins have evolved to cope with the various transport needs …

Tcell antigen receptor (TCR) ligation initiates tyrosine kinase activation, signaling complex
assembly, and immune synapse formation. Here, we studied the kinetics and mechanics of …

Dynactin, a large multisubunit complex, is required for intracellular transport by dynein;
however, its cellular functions and mechanism of action are not clear. Prior studies suggested …

The mitochondrion maintains and regulates its proteome with chaperones primarily inherited
from its bacterial endosymbiont ancestor. Among these chaperones is the AAA+ unfoldase …

Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital
porphyrias, eight forms of which have been described. The genetic penetrance of the …

5-Aminolevulinic acid synthase (ALAS) catalyzes the first step in heme biosynthesis. We
present the crystal structure of a eukaryotic ALAS from Saccharomyces cerevisiae. In this …

The Hepatitis Delta Virus (HDV) ribozyme was the first RNA enzyme proposed to use a
proton-transfer mechanism for catalysis. Previous biochemical evidence suggested that the …

Mitochondria control the activity, quality, and lifetime of their proteins with an autonomous
system of chaperones, but the signals that direct substrate-chaperone interactions and …

Caseinolytic proteases (Clp) are central to bacterial proteolysis and control cellular physiology
and stress responses. They are composed of a double‐ring compartmentalized peptidase …

The mitochondrial matrix GTPase NOA1 is a nuclear encoded protein, essential for
mitochondrial protein synthesis, oxidative phosphorylation and ATP production. Here, we …