Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates …

Recently, RAD51C mutations were identified in families with breast and ovarian cancer 1 .
This observation prompted us to investigate the role of RAD51D in cancer susceptibility. We …

It is frequent for news items to lead to a short lived temporary increase in interest in a particular
health related service, however it is rare for this to have a long lasting effect. In 2013, in …

Improved sequencing technologies offer unprecedented opportunities for investigating the
role of rare genetic variation in common disease. However, there are considerable …

PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and
to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers …

Background Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2,
early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) …

Background Cowden's syndrome is a rare, autosomal dominant disease caused by mutations
in the phosphoinositide 3-kinase and phosphatase and tensin homolog (PTEN) gene. It is …

Background BRCA1 and BRCA2 mutations have been associated with prostate cancer (PCa)
risk but a wide range of risk estimates have been reported that are based on retrospective …

Background Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate
cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-…

Introduction Previous studies have demonstrated that common breast cancer susceptibility
alleles are differentially associated with breast cancer risk for BRCA1 and/or BRCA2 mutation …