Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

JG Hurdle, AJ O'neill, I Chopra, RE Lee - Nature Reviews Microbiology, 2011 - nature.com
Persistent infections involving slow-growing or non-growing bacteria are hard to treat with
antibiotics that target biosynthetic processes in growing cells. Consequently, there is a need …

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

…, X Zhang, WB Stallcup, J Miao, X He, JG Hurdle… - Nature, 2016 - nature.com
Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases
associated with C. difficile infection. Here we carried out CRISPR–Cas9-mediated genome-wide …

Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux

RE Lee, JG Hurdle, J Liu, DF Bruhn, T Matt… - Nature medicine, 2014 - nature.com
Although the classical antibiotic spectinomycin is a potent bacterial protein synthesis inhibitor,
poor antimycobacterial activity limits its clinical application for treating tuberculosis. Using …

The structure–activity relationship of urea derivatives as anti-tuberculosis agents

JR Brown, EJ North, JG Hurdle, C Morisseau… - Bioorganic & medicinal …, 2011 - Elsevier
The treatment of tuberculosis is becoming more difficult due to the ever increasing prevalence
of drug resistance. Thus, it is imperative that novel anti-tuberculosis agents, with unique …

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of …

JG Hurdle, AJ O'Neill, L Mody, I Chopra… - Journal of …, 2005 - academic.oup.com
Objectives: We examined the molecular basis of the emergence of mupirocin resistance in a
methicillin-resistant Staphylococcus aureus (MRSA) strain colonizing a nursing home …

Synthesis, structure–activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives

…, CJ Simmons, YC Tse-Dinh, JG Hurdle… - Journal of medicinal …, 2014 - ACS Publications
On the basis of recently reported abyssinone II and olympicin A, a series of chemically
modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium …

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents

JG Hurdle, RB Lee, NR Budha… - Journal of …, 2008 - academic.oup.com
Objectives Nitrofuranylamides (NFAs) are nitroaromatic compounds that have recently been
discovered and have potent anti-tuberculosis (TB) activity. A foundational study was …

C.difficile intoxicates neurons and pericytes to drive neurogenic inflammation

…, RKR Marreddy, JD Goldsmith, K Yuan, JG Hurdle… - Nature, 2023 - nature.com
Clostridioides difficile infection (CDI) is a major cause of healthcare-associated gastrointestinal
infections 1 , 2 . The exaggerated colonic inflammation caused by C. difficile toxins such …

[HTML][HTML] Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

…, KW Garey, CS Pepperell, JG Hurdle - Nature …, 2023 - nature.com
Severe outbreaks and deaths have been linked to the emergence and global spread of
fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, …

Structural studies of pterin-based inhibitors of dihydropteroate synthase

…, J Qi, ID Kerr, K Babaoglu, JG Hurdle… - Journal of medicinal …, 2010 - ACS Publications
Dihydropteroate synthase (DHPS) is a key enzyme in bacterial folate synthesis and the
target of the sulfonamide class of antibacterials. Resistance and toxicities associated with …